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Republic Of CBD https://www.republicofcbd.com Republic Of CBD Sat, 30 Sep 2017 00:05:24 +0000 en-US hourly 1 https://wordpress.org/?v=5.2.7 What Are Terpenoids? https://www.republicofcbd.com/2017/08/20/where-does-it-come-from/ https://www.republicofcbd.com/2017/08/20/where-does-it-come-from/#respond Sun, 20 Aug 2017 06:10:40 +0000 https://dailynewsalerts.in/rocbd/?p=234 Terpenoids represent the largest and most diverse class of beneficial plant chemicals; more than 40,000 individual terpenoids exist, and new ones are discovered every year
Accumulating research suggests terpenoids may help prevent metabolic disorders, fight cancer, exert antiaging benefits and more
Terpenoids are responsible for the wide variety of plant flavors and aromas, making them a sought-after commodity by the flavor and fragrance industries

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What Are Terpenoids? By Dr. Mercola

Traditional medical practitioners have known for millennia that plants have the power to prevent, treat or otherwise improve a number of medical conditions. Plants contain bioactive phytochemicals, such as tocopherols, polyphenols and ascorbic acid, which perform important functions in both plants and humans.Terpenoids (aka isoprenoids) are another beneficial phytochemical — one that many people haven’t heard of before. Out of the seemingly countless compounds in plants, terpenoids represent the largest and most diverse class of beneficial chemicals.1 More than 40,000 individual terpenoids exist, and new ones are discovered every year.2Plants use terpenoid metabolites to support basic functions like growth, repair and development. However, according to research published in Advances in Biochemical Engineering and Biotechnology, they “use the majority of terpenoids for more specialized chemical interactions and protection.”3Among humans, terpenoids have long been valued for medicinal purposes in traditional Indian and Chinese medicines, and they’ve also been used for food, pharmaceutical and chemical purposes. The cancer drug Taxol and the antimalarial drug artemisinin are both terpenoid-based drugs,4 but the plant compounds are perhaps most well-known for being the main constituents of the essential oils in many plants.Because they’re responsible for the wide variety of plant flavors and aromas — from flowery and fruity notes to woody undertones — they’re a sought-after commodity by the flavor and fragrance industries.5 Further, as noted by a study in the journal Recent Patents on Food, Nutrition & Agriculture:6

“Terpenoids represent the oldest known biomolecules, having been recovered from sediments as old as 2.5 billion years. Among plant secondary metabolites, they are the most abundant and diverse class of natural compounds. The diversity of terpenoids is probably a reflection of their many biological activities in nature, which has made them a widely used resource for traditional and modern human exploitation.”

Eating Terpenoids Daily May Benefit Metabolic Disorders, Including Diabetes

As they pertain to your health, there’s evidence that these powerful plant compounds play a beneficial role in metabolism. According to researchers at Kyoto University in Japan, terpenoids can modulate the activities of ligand-dependent transcription factors, particularly peroxisome proliferator activated receptors (PPARs). PPARs help regulate genes involved in the metabolism of fat and glucose, and PPAR activation has a beneficial effect on blood pressurecholesterol levelsdiabetesheart disease and stroke.“Because PPARs are dietary lipid sensors that control energy homeostasis, daily eating of these terpenoids might be useful for the management for obesity-induced metabolic disorders, such as Type 2 diabetes, hyperlipidemia, insulin resistance and cardiovascular diseases,” the researchers wrote, adding:7

“Dietary patterns rich in vegetables and fruit are associated with a lower prevalence of metabolic syndrome. Because most of the terpenoids are of plant origin and they are contained in vegetables and fruit, dietary terpenoids may contribute to a decrease in risk of metabolic syndrome. Moreover, because the terpenoids constitute one of the largest families of natural products, more potent and useful PPAR activators may exist.”

Terpenoids May Be Valuable as Cancer-Fighting Antioxidants and More

Terpenoids are classified into several classes of chemicals including monoterpenes, diterpenes, triterpenes and tetraterpenes, the latter of which contain the more familiar carotenoids, including lutein and lycopene. Many of them are known for their antioxidant properties as well as their potential for fighting cancer. Lycopene, for instance, may play a role in breast and prostate cancer prevention.A review published in the journal Vitamins and Hormones also noted, “The monoterpenes limonene and perillyl alcohol may be promising substances in cancer therapy,”8 noting that combinations of antioxidants, in particular, may exert synergistic effects.Terpenoids have also been singled out as having potential to prevent and treat liver cancer. According to a study in the World Journal of Hepatology, “A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models.”9Ten new terpenoids, along with 15 known terpenoids, were even shown to reverse multidrug resistance in a multidrug-resistant tumor cell line.10 And nimbolide — a bioactive terpenoid compound found in neem — may shrink prostate tumors by as much as 70 percent while suppressing metastasis by about 50 percent when taken orally for three months.11 The plant compounds have also shown potential as anti-colon cancer agents, with researchers explaining:12

“Anticancer properties of terpenoids are associated with various mechanisms like counteraction of oxidative stress, potentiating endogenous antioxidants, improving detoxification potential, disrupting cell survival pathways and inducing apoptosis.”

In addition, structurally some terpenoids are similar to human hormones, and a diet rich in terpenoids is inversely related with the risk of chronic diseases like cancer, according to research published in Current Drug Targets — including hormone-related cancers like breast and prostate cancers.13 “[Pr]e-clinical studies support clinical application of … naturally occurring terpenoids in treatment of hormone-related human cancers,” the researchers noted.

Terpenoids Are Anti-Inflammatory, Pain-Relieving and More

Beyond their cancer preventive effects, terpenoids also have the following beneficial properties:14

Analgesic (pain relieving) Anti-inflammatory
Antimicrobial Antifungal
Antiviral Antiparasitic

They may also help explain why essential oil therapy can be so effective, as terpenoids are known to affect animal and human behavior when inhaled from ambient air.15 As terpenoids are also found in cannabis, it’s been suggested that terpenoids may work synergistically with cannabinoids to produce some of the beneficial effects of medical marijuana. According to a study in the British Journal of Pharmacology:16

“[Terpenoids] display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts … phytocannabinoid-terpenoid interactions … could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin-resistant Staphylococcus aureus).”

Scientifically Speaking, What Are Terpenoids?

Natural Products Chemistry & Research describes terpenoids as “a large and diverse class of naturally-occurring organic compounds similar to terpenes,” and “any group of hydrocarbons that contain terpenes, derived from five-carbon isoprene units.” They can form cyclic structures such as sterols. Further:

“Most are multicyclic structures that differ from one another not only in functional groups but also in their basic carbon skeletons. These lipids can be found in all classes of living things, and are the largest group of natural products …”17

Most have a fragrance but no color, are lighter than water and volatile with steam (aka “at steam”), at which point it volatilizes, or changes into a gas. A few terpenoids are solids, such as camphor, but all are soluble in organic solvent and usually insoluble in water. Most of them are optically active and many are open-chain or connected, cyclic unsaturated compounds (that form a ring) with one or more double bonds.18

Plants Containing the Most Terpenoids

Terpenoids are found in many living organisms throughout nature, especially plants, fungi and marine animals.19 If you want to increase your intake of these beneficial compounds via your diet, eating more whole plant foods is an excellent way to start. By eating a wide variety, you can be sure you’re consuming a variety of different terpenoids. For example, a list of dietary terpenoids being evaluated for anticancer activity, and their dietary sources, was published in the journal Frontiers in Bioscience:20

  • Monoterpenes: Lemons, oranges, grapefruit, caraway, bergamot, peppermint, spearmint, dill, tomatoes
  • Diterpenes: Carrots, spinach, pumpkin, broccoli, mango, papaya, cherries, tomatoes, oranges, cabbage, watermelon, lettuce
  • Triterpenoids: Olives, mangos, strawberries, grapes, figs
  • Terpenoid chromanols: Almonds, walnuts
  • Carotenoids: Tomatoes, oranges, carrots, peas, sprouts, greens

In addition, thyme and coriander seed oil, which contains up to 70 percent linalool (a terpenoid), are also good sources, as are mushrooms and chamomile. Black seed oil, which is rich in the terpenoid thymoquinone, is another excellent option. Thymoquinone is known to have anticancer effects.21 Research published in Drug Discovery Today concluded thymoquinone has a long history of battling cancer in vitro and in vivo (in “test tube” experiments and animal studies), and modulates 9 of the 10 hallmarks of cancer.22Thymoquinone extract from black cumin appears to be effective against cancers in the blood, lung, kidney, liver, prostate, breast, cervix, colon and skin.23 Black cumin oil is popular in the health food scene, but for optimum nutrition it may be better to use the seeds because essential fatty acids are easily destroyed by heat or prolonged exposure to air. One problem with extracting oil from seeds is that processing is required, so damage is done.I soak the seeds overnight, then put them in a smoothie. They’re a little on the bitter side, so putting sweetener in it such as monk fruit or stevia gives it a tasty boost. Research is ongoing looking into the effects of various terpenoid extracts, such as that from the Siberian fir, a coniferous evergreen tree, which has shown potential anti-aging and anti-cancer effects.24The bottom line is that terpenoids appear to be phenomenal for your health, and if you’d like to consume more of them, the easiest way to do so is to eat more vegetables, herbs and fruits. Beyond that, many plant extracts, essential oils and medicinal plants also contain high concentrations, and working with a holistic health care practitioner who is familiar with some of the different varieties, and their individualized uses, may help you to determine the best sources for you.

What Are Terpenoids?

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A Wine & Weed Collaboration? https://www.republicofcbd.com/2017/08/01/where-can-i-get-some/ https://www.republicofcbd.com/2017/08/01/where-can-i-get-some/#respond Tue, 01 Aug 2017 06:12:56 +0000 https://dailynewsalerts.in/rocbd/?p=236 Opportunities for collaboration include consumer marketing, compliance, cultivation and resources (water, land, and financing)

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The Wine Industry Network (WIN) is hosting the first Wine & Weed Symposium http://wine-weed.com with a focus on the legalization of cannabis in California, expected impact and opportunities for the wine industry, and ways that California wine and cannabis producers can coexist. This educational event will be held on August 3rd at the Hyatt Vineyard Creek in Santa Rosa, CA.
This highly informative event will provide those in the wine trade an opportunity to learn from cannabis experts that understand the challenges of both industries. It’s also a chance for wine professionals to better understand the inevitable competition for consumers and resources (land and water) and to prepare for the changing business environment. To this end, the symposium will also include vendors showcasing products and services for wineries and grape growers interested in expanding into the fast growing cannabis market.
As one can imagine, the wine and cannabis industries have much in common: agriculture, technology, region (AVA), product quality, and marketing to a common consumer. Like the wine industry, cannabis will be heavily regulated and must also deal with legal, financial, compliance and distribution regulations.

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A chronic low dose of THC restores cognitive function in old mice https://www.republicofcbd.com/2017/05/08/why-do-we-use-it/ https://www.republicofcbd.com/2017/05/08/why-do-we-use-it/#respond Mon, 08 May 2017 06:08:28 +0000 https://dailynewsalerts.in/rocbd/?p=232 THC reversed the age-related decline in cognitive performance of mice aged 12 and 18 months

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A chronic low dose of THC restores cognitive function in old mice

The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression of aging. There is substantial evidence suggesting that the endocannabinoid system (ECS) is part of the latter system because it modulates the physiological processes underlying aging12. The activity of the ECS declines during aging, as CB1 receptor expression and coupling to G proteins are reduced in the brain tissues of older animals345 and the levels of the major endocannabinoid 2-arachidonoylglycerol (2-AG) are lower6. However, a direct link between endocannabinoid tone and aging symptoms has not been demonstrated. Here we show that a low dose of Δ9-tetrahydrocannabinol (THC) reversed the age-related decline in cognitive performance of mice aged 12 and 18 months. This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density. THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months. The transcriptional effects of THC were critically dependent on glutamatergic CB1 receptors and histone acetylation, as their inhibition blocked the beneficial effects of THC. Thus, restoration of CB1 signaling in old individuals could be an effective strategy to treat age-related cognitive impairments.

Cannabis helps reverse the effects of brain aging in mice

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Can weed really help you recover from workouts? https://www.republicofcbd.com/2017/01/20/cannabis-and-exercise/ https://www.republicofcbd.com/2017/01/20/cannabis-and-exercise/#respond Fri, 20 Jan 2017 06:07:03 +0000 https://dailynewsalerts.in/rocbd/?p=230 source: Men’s Fitness by Rachael Schultz Anything that can get you back in the gym faster is worth considering. So does marijuana work? Or is the increasingly prevalent cannabis just a bunch of smoke and mirrors when it comes to fitness? We decided to find out. WHEN YOU GET home from a grueling total body HIIT session or a […]

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source: Men’s Fitness by Rachael Schultz

Anything that can get you back in the gym faster is worth considering. So does marijuana work? Or is the increasingly prevalent cannabis just a bunch of smoke and mirrors when it comes to fitness? We decided to find out.

WHEN YOU GET home from a grueling total body HIIT session or a long training run, you know what the next few hours hold: You’ll refuel, rehydrate, and slowly your muscles will start to stiffen and the aches will creep in (good ol’ delayed onset muscle soreness) as your muscles begin to repair and rebuild. Supplements like protein, creatine, and even ibuprofen can all help speed recovery.

The latest “supplement” to be considered for the workout-recovery list: weed. (We’re gonna go ahead and assume it’s legal where you live. OK? OK.) Plenty of people already smoke it, and as it’s become increasingly tolerated around the U.S., plenty more are trying it.

Marijuana can relieve pain and boost recovery, so why is it still legal?

Yet the question remains: Does cannabis help you recover? Or is it snake oil?

Weed and athletic recovery: What does the science say?

“While we have better data on marijuana’s effects than most think, the vast majority is looking for harm instead of benefits and/or is on chronically ill or adolescent populations,” says Jordan Tishler, M.D., a Harvard-trained internist and leading cannabis therapeutics specialist. “We’d love to address these questions with some quality science.”

In other words, there’s slim to no research on how marijuana can positively affect healthy adult guys in general, including as a recovery aid. “Say you run 10 miles and come home and smoke to ease the pain,” Tishler says. What happens? “No one is funding that study right now.”

What we do know: Cannabis probably has zero effect on the process of muscle protein synthesis. Tishler says he hasn’t seen any studies on whether or not cannabis is catabolic. Does marijuana help clean out that biological debris and reduce the swelling that comes with inflammation? We’re not sure of that either. “While cannabis is certainly an anti-inflammatory, it’s unclear if this process works at a sufficient magnitude to actually help heal muscle damage and get you back in the gym faster,” he says.

One way weed definitely helps after workouts

But lighting up post-workout may be able to help you recover faster in one aspect: “It will definitely make delayed onset muscle soreness—or DOMS—less unpleasant, which may lead to getting you back into the gym faster,” Tishler says.

While we don’t have any data on cannabis and the type of pain all gym junkies are most familiar with, we do know that cannabis most certainly alleviates aches. Cannabis significantly reduces chronic pain, according to a massive meta-analysis conducted by the National Academies of Sciences Engineering and Medicine that was released in early 2017. Chronic pain isn’t the same as acute pain, of course—DOMS falls under the latter—but other small studies say cannabis is good for acute pain relief, Tishler says.

The relief is probably comparable to what you’d get from taking an Advil after a run, he says, but it’s less risky. All NSAIDs—that’s nonsteroidal anti-inflammatory drugs, which include ibuprofen and all its derivatives—come with a risk, even slight, when you combine them with exercise. “People tend to think they can use over-the-counter medicine however they want, but they aren’t necessarily safe in all scenarios,” Tishler says. If you’re dehydrated, for example, NSAIDs can increase your risk of rhabdo or full-blown kidney failure. Long-term NSAID use can contribute to ulcers, Tishler adds. “Cannabis, on the other hand, is absolutely safe to use after a workout.”

What’s the best marijuana method for your health?

Edibles have become super trendy, but Tishler isn’t a fan. “Cannabis behaves differently according to how you take it. When you inhale, you get a direct and immediate effect in about 10 minutes. With an edible, you have no gauge for or control over when it will kick in,” he explains. This is where inexperienced users get into trouble: If the effect hasn’t kicked in after an hour, they often just eat another—which just doubles your dose when they both finally hit you. Plus, taking an edible that isn’t going to kick in for two to three hours won’t really help your soreness now.

Tishler’s recommended avenue: vaping flower. “I don’t recommend smoking, since that presents its own harms separate from the kind we see in tobacco. And vape oils are problematic because the process of extraction can involve residual solvents while the cartridges can contain chemicals that aren’t good for you,” he says. “Vaporizing whole cannabis flower is shown to be the healthiest.”


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